Mechanisms for contractile effect of Dai-kenchu-to in isolated guinea pig ileum

The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum. TJ-100 induced contractions accompanied by autonomous contraction at a concentration of more than 3 x 10(-4) g/ml in a dose-related manner. The TJ-10...

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Veröffentlicht in:	Digestive diseases and sciences 2001-02, Vol.46 (2), p.250-256
Hauptverfasser:	SATOH, Kazuko, HAYAKAWA, Terumasa, KASE, Yoshio, ISHIGE, Atsushi, SASAKI, Hiroshi, NISHIKAWA, Shigeto, KUROSAWA, Susumu, YAKABI, Koji, NAKAMURA, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Atropine - pharmacology Biological and medical sciences Digestive system Disease Models, Animal Dose-Response Relationship, Drug Drug Evaluation, Preclinical Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Gastrointestinal Motility - drug effects Guinea Pigs Hexamethonium - pharmacology Ileum - drug effects Indoles - pharmacology Intestinal Pseudo-Obstruction - drug therapy Intestinal Pseudo-Obstruction - physiopathology Male Medical sciences Medicine, Kampo Muscle Contraction - drug effects Muscle, Smooth - drug effects Nicotinic Antagonists - pharmacology Parasympatholytics - pharmacology Pharmaceutical Preparations Pharmacology. Drug treatments Plant Extracts - antagonists & inhibitors Plant Extracts - pharmacology Plant Extracts - therapeutic use Serotonin Antagonists - pharmacology Tetrodotoxin - pharmacology Tropisetron
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Zusammenfassung:	The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum. TJ-100 induced contractions accompanied by autonomous contraction at a concentration of more than 3 x 10(-4) g/ml in a dose-related manner. The TJ-100-induced ileal contraction was suppressed by atropine and tetrodotoxin, but not by hexamethonium. This effect was partially suppressed in the presence of high concentrations of ICS 205-930, a serotonin 4 (5-HT4) receptor antagonist. In addition, TJ-100 showed an acetylcholine (ACh)-releasing action in the smooth muscle tissues of ileum. These results suggest that contractile response induced by TJ-100 is partially mediated by ACh released from the cholinergic nerve endings and that 5-HT4 receptors would be involved in the effect of TJ-100.
ISSN:	0163-2116 1573-2568
DOI:	10.1023/a:1005636412287