Rate of Pathologic Complete Response With Increased Interval Between Preoperative Combined Modality Therapy and Rectal Cancer Resection

INTRODUCTION: METHODS: RESULTS:A pathologic complete response (ypT0N0) occurred in 24 patients (15 percent). Median RT-surgery interval was 44 (range, 15-206) days. A pathologic complete response occurred in 19 percent of patients with an interval >44 days, vs. 12 percent in those with an interva...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diseases of the colon & rectum 2004-03, Vol.47 (3), p.279-286
Hauptverfasser:	Moore, Harvey G, Gittleman, Alicia E, Minsky, Bruce D, Wong, Douglas, Paty, Philip B, Weiser, Martin, Temple, Larissa, Saltz, Leonard, Shia, Jinru, Guillem, Jose G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Anal Canal - physiology Anal Canal - surgery Antimetabolites, Antineoplastic - therapeutic use Biological and medical sciences Combined Modality Therapy Endosonography Female Fluorouracil - therapeutic use Gastroenterology. Liver. Pancreas. Abdomen Humans Length of Stay Male Medical sciences Middle Aged Neoplasm Staging Postoperative Complications Preoperative Care - methods Rectal Neoplasms - diagnostic imaging Rectal Neoplasms - pathology Rectal Neoplasms - therapy Retrospective Studies Time Factors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	INTRODUCTION: METHODS: RESULTS:A pathologic complete response (ypT0N0) occurred in 24 patients (15 percent). Median RT-surgery interval was 44 (range, 15-206) days. A pathologic complete response occurred in 19 percent of patients with an interval >44 days, vs. 12 percent in those with an interval ≤44 days (P = 0.27). Downstaging by three stages occurred more frequently in the long-interval group (15 percent vs. 6 percent, P = 0.11). The rates of sphincter preservation, positive margins, estimated blood loss, and operative time were not significantly different. Overall morbidity was similar between groups. CONCLUSIONS:
ISSN:	0012-3706 1530-0358
DOI:	10.1007/s10350-003-0062-1