Improvement of Colonic Healing by Preoperative Rectal Irrigation With Short-Chain Fatty Acids in Rats Given Radiotherapy

BACKGROUND: METHODS: RESULTS:The mean bursting pressure was significantly low in Group III on Day 3 and was significantly high in Group IV on Day 7 (P = 0.001, P = 0.021). The burst occurred at the anastomoses in all animals tested on the third postoperative day, and outside of the anastomoses in al...

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Veröffentlicht in:Diseases of the colon & rectum 2004-12, Vol.47 (12), p.2184-2194
Hauptverfasser: Terzi, Cem, Sevinç, Ali İbrahim, Koçdor, Hilal, Oktay, Gülgün, Alanyal, Hilmi, Küpelioğlu, Ali, Ergör, Gül, Füzün, Mehmet
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Sprache:eng
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Zusammenfassung:BACKGROUND: METHODS: RESULTS:The mean bursting pressure was significantly low in Group III on Day 3 and was significantly high in Group IV on Day 7 (P = 0.001, P = 0.021). The burst occurred at the anastomoses in all animals tested on the third postoperative day, and outside of the anastomoses in all animals tested on the seventh postoperative day. The histologic parameters of anastomotic healing, such as epithelial regeneration and formation of granulation tissue, were significantly improved by use of preoperative rectal irrigation with short-chain fatty acids on Day 7. The amount of total and salt-soluble collagen concentrations significantly increased in Group IV compared with the control group on Day 3 (P = 0.008, P = 0.004). CONCLUSION:
ISSN:0012-3706
1530-0358
DOI:10.1007/s10350-004-0724-7