Treatment of Chronic Anal Fissure by Application of l-Arginine Gel: A Phase II Study in 15 Patients

PURPOSE: METHODS: RESULTS:One patient dropped out after one day of treatment, and one was excluded because of violation of the study protocol. After 12 weeks of treatment complete fissure healing was observed in 3 of 13 (23 percent) patients, and after 18 weeks the healing rate was 8 of 13 (62 perce...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Diseases of the colon & rectum 2005-04, Vol.48 (4), p.832-837
Hauptverfasser:	Gosselink, M P, Darby, M, Zimmerman, D D. E, Gruss, H J, Schouten, W R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adult Anal Canal - blood supply Arginine - administration & dosage Arginine - adverse effects Arginine - therapeutic use Biological and medical sciences Chronic Disease Female Fissure in Ano - drug therapy Gastroenterology. Liver. Pancreas. Abdomen Headache - chemically induced Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Manometry Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Other diseases. Semiology Pressure Regional Blood Flow Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Treatment Outcome Wound Healing
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	PURPOSE: METHODS: RESULTS:One patient dropped out after one day of treatment, and one was excluded because of violation of the study protocol. After 12 weeks of treatment complete fissure healing was observed in 3 of 13 (23 percent) patients, and after 18 weeks the healing rate was 8 of 13 (62 percent) patients. None of the 13 patients experienced typical nitric oxide-induced headache. The pressure recordings showed a significant reduction of maximum anal resting pressure (mean ± SD)pretreatment 89 ± 17 mmHg; 20 minutes after application of the first dose 67 ± 17 mmHg; 12 weeks after treatment 74 ± 14 mmHg (P < 0.005). Recordings of anodermal blood flow showed a significant increase in flowpretreatment 0.36 ± 0.25 volts; 20 minutes after application of the first dose 0.59 ± 0.27; 12 weeks after treatment 0.64 ± 0.33 (P < 0.005). CONCLUSIONS:
ISSN:	0012-3706 1530-0358
DOI:	10.1007/s10350-004-0858-7