Randomized Clinical Trial of Botulinum Toxin Plus Glyceryl Trinitrate vs. Botulinum Toxin Alone for Medically Resistant Chronic Anal Fissure: Overall Poor Healing Rates

PURPOSE: METHODS: RESULTS:Thirty patients were randomized. Two-thirds of patients had maximum anal resting pressures below or within the normal range at entry to the study. Healing rates in both treatment groups were disappointing. There was a nonsignificant trend to better outcomes in Group A compa...

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