Randomized Clinical Trial of Botulinum Toxin Plus Glyceryl Trinitrate vs. Botulinum Toxin Alone for Medically Resistant Chronic Anal Fissure: Overall Poor Healing Rates

PURPOSE: METHODS: RESULTS:Thirty patients were randomized. Two-thirds of patients had maximum anal resting pressures below or within the normal range at entry to the study. Healing rates in both treatment groups were disappointing. There was a nonsignificant trend to better outcomes in Group A compa...

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Veröffentlicht in:	Diseases of the colon & rectum 2006-10, Vol.49 (10), p.1574-1580
Hauptverfasser:	Jones, O M, Ramalingam, T, Merrie, A, Cunningham, C, George, B D, Mortensen, N J. McC, Lindsey, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Botulinum Toxins - therapeutic use Drug Therapy, Combination Female Fissure in Ano - drug therapy Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Nitric Oxide Donors - therapeutic use Nitroglycerin - therapeutic use Other diseases. Semiology Poisons - therapeutic use Pressure Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Wound Healing - drug effects
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Zusammenfassung:	PURPOSE: METHODS: RESULTS:Thirty patients were randomized. Two-thirds of patients had maximum anal resting pressures below or within the normal range at entry to the study. Healing rates in both treatment groups were disappointing. There was a nonsignificant trend to better outcomes in Group A compared with Group B in terms of fissure healing (47 vs. 27 percent), symptomatic improvement (87 vs. 67 percent), and resort to surgery (27 vs. 47 percent). CONCLUSIONS:
ISSN:	0012-3706 1530-0358
DOI:	10.1007/s10350-006-0679-y