Randomized Clinical Trial of Botulinum Toxin Plus Glyceryl Trinitrate vs. Botulinum Toxin Alone for Medically Resistant Chronic Anal Fissure: Overall Poor Healing Rates

PURPOSE: METHODS: RESULTS:Thirty patients were randomized. Two-thirds of patients had maximum anal resting pressures below or within the normal range at entry to the study. Healing rates in both treatment groups were disappointing. There was a nonsignificant trend to better outcomes in Group A compa...

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Veröffentlicht in:	Diseases of the colon & rectum 2006-10, Vol.49 (10), p.1574-1580
Hauptverfasser:	Jones, O M, Ramalingam, T, Merrie, A, Cunningham, C, George, B D, Mortensen, N J. McC, Lindsey, I
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Biological and medical sciences Botulinum Toxins - therapeutic use Drug Therapy, Combination Female Fissure in Ano - drug therapy Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Nitric Oxide Donors - therapeutic use Nitroglycerin - therapeutic use Other diseases. Semiology Poisons - therapeutic use Pressure Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Wound Healing - drug effects
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container_title	Diseases of the colon & rectum
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creator	Jones, O M Ramalingam, T Merrie, A Cunningham, C George, B D Mortensen, N J. McC Lindsey, I
description	PURPOSE: METHODS: RESULTS:Thirty patients were randomized. Two-thirds of patients had maximum anal resting pressures below or within the normal range at entry to the study. Healing rates in both treatment groups were disappointing. There was a nonsignificant trend to better outcomes in Group A compared with Group B in terms of fissure healing (47 vs. 27 percent), symptomatic improvement (87 vs. 67 percent), and resort to surgery (27 vs. 47 percent). CONCLUSIONS:
doi_str_mv	10.1007/s10350-006-0679-y
format	Article
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McC</creatorcontrib><creatorcontrib>Lindsey, I</creatorcontrib><title>Randomized Clinical Trial of Botulinum Toxin Plus Glyceryl Trinitrate vs. Botulinum Toxin Alone for Medically Resistant Chronic Anal Fissure: Overall Poor Healing Rates</title><title>Diseases of the colon & rectum</title><addtitle>Dis Colon Rectum</addtitle><description>PURPOSE: METHODS: RESULTS:Thirty patients were randomized. Two-thirds of patients had maximum anal resting pressures below or within the normal range at entry to the study. Healing rates in both treatment groups were disappointing. There was a nonsignificant trend to better outcomes in Group A compared with Group B in terms of fissure healing (47 vs. 27 percent), symptomatic improvement (87 vs. 67 percent), and resort to surgery (27 vs. 47 percent). CONCLUSIONS:</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Botulinum Toxins - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fissure in Ano - drug therapy</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitric Oxide Donors - therapeutic use</subject><subject>Nitroglycerin - therapeutic use</subject><subject>Other diseases. Semiology</subject><subject>Poisons - therapeutic use</subject><subject>Pressure</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. 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McC</creator><creator>Lindsey, I</creator><general>The ASCRS</general><general>Springer</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>200610</creationdate><title>Randomized Clinical Trial of Botulinum Toxin Plus Glyceryl Trinitrate vs. Botulinum Toxin Alone for Medically Resistant Chronic Anal Fissure: Overall Poor Healing Rates</title><author>Jones, O M ; Ramalingam, T ; Merrie, A ; Cunningham, C ; George, B D ; Mortensen, N J. 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source	MEDLINE; SpringerLink Journals; Journals@Ovid Complete
subjects	Adult Aged Biological and medical sciences Botulinum Toxins - therapeutic use Drug Therapy, Combination Female Fissure in Ano - drug therapy Gastroenterology. Liver. Pancreas. Abdomen Humans Male Medical sciences Middle Aged Nitric Oxide Donors - therapeutic use Nitroglycerin - therapeutic use Other diseases. Semiology Poisons - therapeutic use Pressure Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Time Factors Wound Healing - drug effects
title	Randomized Clinical Trial of Botulinum Toxin Plus Glyceryl Trinitrate vs. Botulinum Toxin Alone for Medically Resistant Chronic Anal Fissure: Overall Poor Healing Rates
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