Use of Capillary Zone Electrophoresis for Differentiating Excessive from Moderate Alcohol Consumption

The poorly sialylated transferrin isoforms in serum were analyzed by capillary zone electrophoresis (CZE) to differentiate moderate from heavy alcohol consumption. We enrolled 614 volunteers, classified after interviews, self-reported drinking habits, and AUDIT scores as alcohol abusers (consuming &...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2003-03, Vol.49 (3), p.440-449
Hauptverfasser:	Legros, Franz J, Nuyens, Vincent, Baudoux, Michel, Zouaoui Boudjeltia, Karim, Ruelle, Jean-Luc, Colicis, Jacques, Cantraine, Francis, Henry, Jean-Pol
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Alcohol Drinking Alcoholism - diagnosis Alcohols Asialoglycoproteins - analysis Biological and medical sciences Biomarkers - blood Capillary zone Diagnosis, Differential Electrophoresis Electrophoresis, Capillary Ethanol Female Humans Immunoassay Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Metabolic diseases Middle Aged Nephelometry and Turbidimetry Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Protein Isoforms ROC Curve Sex Factors Silica Transferrin - analogs & derivatives Transferrin - analysis
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Zusammenfassung:	The poorly sialylated transferrin isoforms in serum were analyzed by capillary zone electrophoresis (CZE) to differentiate moderate from heavy alcohol consumption. We enrolled 614 volunteers, classified after interviews, self-reported drinking habits, and AUDIT scores as alcohol abusers (consuming >50 g/day ethanol for the previous 3 months or longer; n = 413) or moderate drinkers (
ISSN:	0009-9147 1530-8561
DOI:	10.1373/49.3.440