Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia

Monozygotic twins diagnosed simultaneously with RAM immunophenotype acute myeloid leukemia

AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone...

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Veröffentlicht in:Pediatric transplantation 2018-12, Vol.22 (8), p.e13291-n/a
Hauptverfasser: Abu‐Arja, Rolla F., Dargart, Jamie L., Bajwa, Rajinder P. S., Kahwash, Samir B., Auletta, Jeffery J., Rangarajan, Hemalatha G.
Format: Artikel
Sprache:eng
Schlagworte:
Acute myeloid leukemia
AML
Bone marrow
Bone marrow transplantation
Chemotherapy
Cord blood
Flow cytometry
Graft rejection
Grafts
Hematopoietic stem cells
Myeloid leukemia
RAM phenotype
Remission
Stem cells
Twins
Umbilical cord
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Zusammenfassung:AML with the RAM immunophenotype is associated with extremely poor prognosis. We report a rare case of monozygotic twins presenting simultaneously at the age of 2 years with RAM AML. Each twin underwent a myeloablative 7/10 unrelated umbilical cord blood transplant. Pretransplant Twin A's bone marrow was negative for MRD by flow cytometry (
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.13291