CONGENITAL CONNECTIVE-TISSUE DEFECT PROBABLY DUE TO D-PENICILLAMINE TREATMENT IN PREGNANCY

CONGENITAL CONNECTIVE-TISSUE DEFECT PROBABLY DUE TO D-PENICILLAMINE TREATMENT IN PREGNANCY

A young woman with severe cystinuria was treated with 2 g. D-penicillamine daily during pregnancy. She gave birth to a child with a generalised connective-tissue defect including lax skin, hyperflexibility of the joints, vein fragility, varicosities, and impaired wound healing. D-penicillamine was p...

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Veröffentlicht in:The Lancet (British edition) 1971-04, Vol.297 (7701), p.673-675
Hauptverfasser: Mjølnerød, O.K., Dommerud, S.A., Rasmussen, K., Gjeruldsen, S.T.
Format: Artikel
Sprache:eng
Schlagworte:
Cystinuria
Defects
Fragility
Pregnancy
Skin
Wound healing
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Zusammenfassung:A young woman with severe cystinuria was treated with 2 g. D-penicillamine daily during pregnancy. She gave birth to a child with a generalised connective-tissue defect including lax skin, hyperflexibility of the joints, vein fragility, varicosities, and impaired wound healing. D-penicillamine was probably the cause of this defect. The child died of septicæmia aged 7 weeks.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(71)92681-X