Case series and systematic review of acquired diaphragmatic hernia after liver transplantation
Background ADH is a rare and potentially fatal complication following LT. In this study, a systematic review was completed to identify risk factors which may contribute to ADH. Methods Transplant databases at three LT programs were reviewed. Four pediatric and zero adult cases were identified. Next,...
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Veröffentlicht in: | Pediatric transplantation 2018-12, Vol.22 (8), p.e13296-n/a |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background
ADH is a rare and potentially fatal complication following LT. In this study, a systematic review was completed to identify risk factors which may contribute to ADH.
Methods
Transplant databases at three LT programs were reviewed. Four pediatric and zero adult cases were identified. Next, a systematic review was completed. Fourteen studies describing 41 patients with ADH were identified. Patient demographics, transplant characteristics, and features of ADH diagnosis were examined.
Results
The majority (90.2%) of ADH were in children. In pediatric LT, 95.1% received a segmental allograft. ADH occurred in the right P diaphragm 92.7% of the time, and 87.8% were repaired primarily. Patient demographics, post‐transplant complications, and immunosuppression regimens were broad and failed to predict ADH. Most patients presented with either respiratory or gastrointestinal symptoms. There were two pediatric deaths related to undiagnosed ADH. The combined worldwide incidence of ADH in pediatric LT is 1.5% (34/2319 patients).
Conclusion
ADH is a rare complication post‐LT that primarily occurs in pediatric recipients. When diagnosed early, ADH can be repaired primarily with good outcomes. |
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ISSN: | 1397-3142 1399-3046 |
DOI: | 10.1111/petr.13296 |