Flupenthixol and cefotiam: effects on vitamin A metabolism in rats

We examined the alterations in vitamin A metabolism as a result of flupenthixol or cefotiam administration. The impact of these drugs on indices of vitamin A status was evaluated in Brown Norway and Long–Evans rats. Intramuscular drug administration for 28 d resulted in a decline in systemic retinol...

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Veröffentlicht in:	British journal of nutrition 2004-10, Vol.92 (4), p.597-605
Hauptverfasser:	Schindler, Rainer, Fielenbach, Tanja, Rave, Gerhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antibiotics Biological and medical sciences Carboxylic Ester Hydrolases - metabolism Cefotiam - pharmacology Cefotiam–vitamin A interaction Cytochrome Drug Interactions Drugs Enzymes Esters Flupenthixol - pharmacology Flupenthixol–vitamin A interaction Human subjects Infections Kidney - metabolism Liver Liver - metabolism Male Medical sciences Metabolism Neuropharmacology Penicillin Peritoneal dialysis Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred BN Rats, Long-Evans Retinyl ester hydrolase Vitamin A Vitamin A - blood Vitamin A - metabolism Weight Gain - drug effects Xenobiotics
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Zusammenfassung:	We examined the alterations in vitamin A metabolism as a result of flupenthixol or cefotiam administration. The impact of these drugs on indices of vitamin A status was evaluated in Brown Norway and Long–Evans rats. Intramuscular drug administration for 28 d resulted in a decline in systemic retinol. Changes in circulating retinol with time for chronic dosing showed drug treatment (P
ISSN:	0007-1145 1475-2662
DOI:	10.1079/BJN20041236