PS-043 Perinatal Factors Associated With Survival In Infants At The Limit Of Viability

Background and aimsDecisions in pregnancies at the limit of viability are usually taken primarily based on gestational age. Other factors, however, may be critical to the results. The aim of our study was to know which perinatal factors are associated with survival in neonates ≤ 26 weeks GA.MethodsRetrospective analysis of prospectively collected data. We included all inborn infants ≤ 26 weeks GA without major congenital malformations, admitted to the NICUs participating in the Spanish SEN1500 network, during the period 2004–2010. The relation of risk factors to the likelihood of survival was analysed with the Cox Proportional-Hazards Regression method.ResultsDuring the study period 3,915 infants ≤ 26 weeks GA were born alive. Of these, 3,518 (89,9%) were “inborns”. Infants who died in the delivery room and/or who had severe congenital malformations were excluded. Finally, 3,236 patients were included. After correcting for potential confounders, survival was related to the following antenatal and postnatal variables:Abstract PS-043 Table 1VariablesOR95% CIpGestational age1.6651,507–1,839< 0.001Birth weight1.0031,003–1,004< 0.001Antenatal steroids2.8052,270–3,467< 0.001Sex (male)0.7160,610–0,840< 0.001Multiple gestation0.6970,588–0,826< 0.001Admission temperature1.3971.222–1.597< 0.001CRIB score I0.8450.815–0.876< 0.001ConclusionsGA, birth weight, female sex, antenatal steroid and single gestation are factors potentially known prenatally that are associate with a higher probability of survival. After birth, in the first 12 h after admission, the CRIB I score and the temperature at admission were independently associated with differences in survival.