PO-0424 Does Supplementary Oxygen During A Desaturation Cause Cerebral Hyperoxia In Preterm Neonates?

BackgroundSupplementary oxygen is often administered when preterm neonates experience desaturations i.e. after apnea, sometimes resulting in cerebral hyperoxia during recovery. Whether this post-hypoxic cerebral hyperoxia is induced by the supplementary oxygen, remains unknown.AimTo compare the regional cerebral oxygen saturation (rcSO2) and cerebral fractional oxygen extraction (cFTOE) following a desaturation, between preterm neonates who did and did not receive supplementary oxygen.MethodsAs part of a larger prospective cohort study, near infrared spectroscopy (NIRS) was used to measure rcSO2 during days 2 to 5 after birth. We collected 50 consecutive desaturations (SpO2