PO-0744 Genome-wide Association Study Of Bronchopulmonary Dysplasia

Background and aimsBronchopulmonary dysplasia (BPD) is the most common chronic disease associated with very preterm birth. BPD has a significant genetic background but the predisposing genes are insufficiently known. The aim is to find genetic factors that predispose to moderate-severe BPD using a h...

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Veröffentlicht in:	Archives of disease in childhood 2014-10, Vol.99 (Suppl 2), p.A498-A499
Hauptverfasser:	Karjalainen, MK, Mahlman, M, Huusko, JM, Andersson, S, Kari, A, Lehtonen, L, Sankilampi, U, Tammela, O, Marttila, R, Rämet, M, Hallman, M
Format:	Artikel
Sprache:	eng
Schlagworte:	C-reactive protein Dysplasia Genetic factors Genetics Genome-wide association studies Genomes Gestational age Infants Lung diseases Population studies Premature birth Protein-tyrosine-phosphatase Quality control SHP-1 protein Single-nucleotide polymorphism Young Children
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Beschreibung
Zusammenfassung:	Background and aimsBronchopulmonary dysplasia (BPD) is the most common chronic disease associated with very preterm birth. BPD has a significant genetic background but the predisposing genes are insufficiently known. The aim is to find genetic factors that predispose to moderate-severe BPD using a hypothesis-free, genome-wide approach.MethodsThe study populations included preterm infants (gestational age
ISSN:	0003-9888 1468-2044
DOI:	10.1136/archdischild-2014-307384.1383