Design, Synthesis, and Anticancer Evaluation of Tetrazole-Fused Benzoxazole Derivatives as Tubulin Binding Agents
A novel series of tetrazole fused benzoxazole derivatives 9a – 9j are synthesized, and their structures are characterized by 1 H and 13 C NMR, and mass spectra. The compounds 9a , 9b , 9g , 9h , and 9j demonstrate the highest activity. The compounds 9b and 9g exhibit good anticancer activity, in par...
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Veröffentlicht in: | Russian journal of general chemistry 2018-10, Vol.88 (10), p.2183-2189 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
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Zusammenfassung: | A novel series of tetrazole fused benzoxazole derivatives
9a
–
9j
are synthesized, and their structures are characterized by
1
H and
13
C NMR, and mass spectra. The compounds
9a
,
9b
,
9g
,
9h
, and
9j
demonstrate the highest activity. The compounds
9b
and
9g
exhibit good anticancer activity, in particular against MCF7, Hop62, and A-549 cell lines with the range of GI
50
values from |
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ISSN: | 1070-3632 1608-3350 |
DOI: | 10.1134/S1070363218100250 |