Diversity‐Oriented Approach to Spirorhodanines via a [2+2+2] Cyclotrimerization

Spirocyclic compounds have been increasingly utilized in drug discovery due to their inherent three‐dimensional structural complexity. Here, we report a diversity oriented approach to spirorhodanines via a [2+2+2] cyclotrimerization reaction with propargyl halides as co‐partners. In another sequence, we employed o‐xylylene dibromide as a coupling partner to assemble spirorhodanines. Mo(CO)6 was used as a catalyst for the synthesis of spirorhodanine derivatives with propargyl halides as co‐partners, via a [2+2+2] cyclotrimerization reaction. Synthesis of spirorhodanines by utilizing o‐xylylene dibromide was also developed.