Effect of compound LBK-149 on antiarrhythmic activity of lidocaine in rats with arrhythmias and disturbances in lipid and carbohydrate metabolism

Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.

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Veröffentlicht in:Bulletin of experimental biology and medicine 2007-03, Vol.143 (3), p.331-333
Hauptverfasser: Artem'eva, O V, Koryaikina, A V, Zor'kina, A V
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container_title Bulletin of experimental biology and medicine
container_volume 143
creator Artem'eva, O V
Koryaikina, A V
Zor'kina, A V
description Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.
doi_str_mv 10.1007/s10517-007-0103-1
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subjects Animals
Anti-Arrhythmia Agents - administration & dosage
Antiarrhythmics
Antioxidants - administration & dosage
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - metabolism
Carbohydrate Metabolism - drug effects
Drug Synergism
Female
Lidocaine - administration & dosage
Lipid Metabolism - drug effects
Lipid Peroxidation - drug effects
Male
Rats
title Effect of compound LBK-149 on antiarrhythmic activity of lidocaine in rats with arrhythmias and disturbances in lipid and carbohydrate metabolism
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