Effect of compound LBK-149 on antiarrhythmic activity of lidocaine in rats with arrhythmias and disturbances in lipid and carbohydrate metabolism

Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.

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Bibliographische Detailangaben
Veröffentlicht in:	Bulletin of experimental biology and medicine 2007-03, Vol.143 (3), p.331-333
Hauptverfasser:	Artem'eva, O V, Koryaikina, A V, Zor'kina, A V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Arrhythmia Agents - administration & dosage Antiarrhythmics Antioxidants - administration & dosage Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - metabolism Carbohydrate Metabolism - drug effects Drug Synergism Female Lidocaine - administration & dosage Lipid Metabolism - drug effects Lipid Peroxidation - drug effects Male Rats
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Beschreibung
Zusammenfassung:	Antiarrhythmic activity of lidocaine during early occlusion and reperfusion arrhythmias decreased in rats with experimental disturbances in lipid and carbohydrate metabolism. The course of additional treatment with compound LBK-149 potentiated antiarrhythmic activity of lidocaine.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-007-0103-1