Possible Role of the Phosphoinositide Pathway for Signal Transduction in Changes in the Sensitivity of [delta]-Opiate Receptors during Diabetes Mellitus

We studied the effects of selective delta-opiate receptor agonists and antagonists on the phosphoinositide pathway in lymphocytes from healthy donors and patients with diabetes mellitus. The test compounds probably play a role in changes in the sensitivity to pharmacological substances binding to delta-opiate receptors during diabetes mellitus.