Effect of administration of lead nitrate to pregnant rats on the lungs in their offspring

Lead nitrate in a dose of 200 mg/kg was administered to female rats via a gartric tube on days 5 and 12 of pregnancy. The lungs of their offspring were examined on day 40 of life. We found a decrease in the ratio between the specific volumes of alveolar lumens and interalveolar septa and hypertrophy...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-06, Vol.139 (6), p.655-657
Hauptverfasser:	Lebed'ko, O A, Ryzhavskii, B Ya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Female Lead - administration & dosage Lead - toxicity Lung - drug effects Lung - metabolism Lung - physiology Lung Diseases - chemically induced Lung Diseases - metabolism Lung Diseases - pathology Lung Diseases - physiopathology Lung Volume Measurements Nitrates - administration & dosage Nitrates - toxicity Oxidation-Reduction Pregnancy Prenatal Exposure Delayed Effects Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Rats Reactive Oxygen Species - metabolism
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Beschreibung
Zusammenfassung:	Lead nitrate in a dose of 200 mg/kg was administered to female rats via a gartric tube on days 5 and 12 of pregnancy. The lungs of their offspring were examined on day 40 of life. We found a decrease in the ratio between the specific volumes of alveolar lumens and interalveolar septa and hypertrophy of lymphoid tissue in the bronchial wall (compared to the offspring of intact females). Chemiluminescent analysis revealed activation of lipid peroxidation and decrease in antioxidant antiradical activity of the lungs.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0369-0