Effect of radiation on prothrombin interactions with cell membrane fragments
Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the mol...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2002-11, Vol.134 (5), p.442 |
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| container_issue | 5 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Kiselev, S V Zubairov, D M Kirshin, S V |
| description | Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the molecular basis for increased thrombogenicity of cell membranes. |
| doi_str_mv | 10.1023/A:1022630011907 |
| format | Article |
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Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the molecular basis for increased thrombogenicity of cell membranes.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1023/A:1022630011907</identifier><identifier>PMID: 12802446</identifier><identifier>CODEN: BEXBAN</identifier><language>eng</language><publisher>United States: Springer Nature B.V</publisher><subject>Animals ; Aorta, Thoracic - injuries ; Aorta, Thoracic - metabolism ; Aorta, Thoracic - radiation effects ; Cell Membrane - metabolism ; Cell Membrane - radiation effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; In Vitro Techniques ; Iodine Radioisotopes ; Kinetics ; Membrane Lipids - metabolism ; Membrane Lipids - radiation effects ; Phospholipids - metabolism ; Phospholipids - radiation effects ; Prothrombin - metabolism ; Radiation Injuries - metabolism ; Sus scrofa ; Thrombosis - etiology</subject><ispartof>Bulletin of experimental biology and medicine, 2002-11, Vol.134 (5), p.442</ispartof><rights>Copyright Kluwer Academic Publishers Nov 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12802446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kiselev, S V</creatorcontrib><creatorcontrib>Zubairov, D M</creatorcontrib><creatorcontrib>Kirshin, S V</creatorcontrib><title>Effect of radiation on prothrombin interactions with cell membrane fragments</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><description>Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. 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| fulltext | fulltext |
| identifier | ISSN: 0007-4888 |
| ispartof | Bulletin of experimental biology and medicine, 2002-11, Vol.134 (5), p.442 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Aorta, Thoracic - injuries Aorta, Thoracic - metabolism Aorta, Thoracic - radiation effects Cell Membrane - metabolism Cell Membrane - radiation effects Dose-Response Relationship, Radiation Gamma Rays In Vitro Techniques Iodine Radioisotopes Kinetics Membrane Lipids - metabolism Membrane Lipids - radiation effects Phospholipids - metabolism Phospholipids - radiation effects Prothrombin - metabolism Radiation Injuries - metabolism Sus scrofa Thrombosis - etiology |
| title | Effect of radiation on prothrombin interactions with cell membrane fragments |
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