Effect of radiation on prothrombin interactions with cell membrane fragments

Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the mol...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2002-11, Vol.134 (5), p.442
Hauptverfasser:	Kiselev, S V, Zubairov, D M, Kirshin, S V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta, Thoracic - injuries Aorta, Thoracic - metabolism Aorta, Thoracic - radiation effects Cell Membrane - metabolism Cell Membrane - radiation effects Dose-Response Relationship, Radiation Gamma Rays In Vitro Techniques Iodine Radioisotopes Kinetics Membrane Lipids - metabolism Membrane Lipids - radiation effects Phospholipids - metabolism Phospholipids - radiation effects Prothrombin - metabolism Radiation Injuries - metabolism Sus scrofa Thrombosis - etiology
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Zusammenfassung:	Binding of (125)I-labeled prothrombin to normal and radiation-damaged (1 and 3.5 Gy) fragments of cell membranes was studied. Irradiation significantly increased adsorption capacity of cell membranes for (125)I-prothrombin. It was concluded that phase rearrangement of phospholipids serves as the molecular basis for increased thrombogenicity of cell membranes.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/A:1022630011907