Protective effect of energy metabolism regulators in alteration of gravitation load under experimental conditions

Protective effect of energy metabolism regulators in alteration of gravitation load under experimental conditions

Mitochondrial substrate-based preparations corrected disorders, caused by long-term exposure to abnormal gravitation vector in head-down tilt (hanging) test in rats. The preparations produced systemic and polyorgan protective effects consisting in correction of the blood prooxidant/antioxidant balan...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2006-10, Vol.142 (4), p.441-446
Hauptverfasser: Mazina, N K, Larina, I M, Khazanov, V A, Shenkman, B S, Tsapok, P I, Zaitsev, V B, Khorobrykh, V G, Veselova, O M, Tret'yakov, V S
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Antioxidants - metabolism
Energy Metabolism - drug effects
Gravitation
Head-Down Tilt
Malates - pharmacology
Male
Mitochondria - metabolism
Oxidants - blood
Rats
Rats, Wistar
Succinic Acid - pharmacology
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Zusammenfassung:Mitochondrial substrate-based preparations corrected disorders, caused by long-term exposure to abnormal gravitation vector in head-down tilt (hanging) test in rats. The preparations produced systemic and polyorgan protective effects consisting in correction of the blood prooxidant/antioxidant balance, energy metabolism in musculus soleus, and minimization of morphological changes in the liver and kidneys.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0387-6