Effects of cytotoxins on intracellular Na/K balance in mouse embryonic cell

Cytoplasmic Na/K imbalance induced by cytotoxic substances (ethylene glycol and cytochalasin B) was studied. Incubation in Dulbecco's medium with these cytotoxins caused changes in K and Na concentrations in the mouse two-cell embryo blastomer. The effects of both substances resulted in a drop...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-04, Vol.145 (4), p.531-534
Hauptverfasser:	Pogorelov, A. G, Goldshtein, D. V, Pogorelova, V. N
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Biomedical and Life Sciences Biomedicine Cell Biology cytochalasin B Cytochalasin B - pharmacology cytoplasmic Na/K balance Cytotoxins - pharmacology electron probe microanalysis Embryo, Mammalian Embryonic Development - drug effects Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism ethylene glycol Ethylene Glycol - pharmacology Homeostasis - drug effects Internal Medicine Intracellular Fluid - chemistry Intracellular Fluid - drug effects Intracellular Fluid - metabolism Laboratory Medicine Mice Mice, Inbred C57BL Mice, Inbred CBA mouse embryonic cell Pathology Potassium - analysis Potassium - metabolism Sodium - analysis Sodium - metabolism Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
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Zusammenfassung:	Cytoplasmic Na/K imbalance induced by cytotoxic substances (ethylene glycol and cytochalasin B) was studied. Incubation in Dulbecco's medium with these cytotoxins caused changes in K and Na concentrations in the mouse two-cell embryo blastomer. The effects of both substances resulted in a drop of Na content in the embryonic cell. Washing from cytochalasin B restored the initial Na/K balance in the cytoplasm. Possible adaptive mechanisms involved in the regulation of intracellular ionic homeostasis are discussed.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-008-0134-2