Induction of NO-synthase and acetaldehyde dehydrogenase in neurons of human cerebellar cortex during chronic alcohol intoxication

Induction of NO-synthase and acetaldehyde dehydrogenase in Purkinje cells, basket-like neurons, and microvascular endothelium of human cerebellar cortex was detected in patients with chronic alcohol intoxication. It was hypothesized that the neuromodulating effect of NO is associated with mechanisms...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2004-02, Vol.137 (2), p.211-214
Hauptverfasser:	Konovko, O O, Morozov, Yu E, Kalinichenko, S G, Dyuzen, I V, Motavkin, P A
Format:	Artikel
Sprache:	eng ; rus
Schlagworte:	Adult Alcoholism - enzymology Aldehyde Oxidoreductases - biosynthesis Cerebellar Cortex - enzymology Endothelium, Vascular - enzymology Enzyme Induction Humans In Vitro Techniques Middle Aged NADPH Dehydrogenase - biosynthesis Neurons - enzymology Nitric Oxide Synthase - biosynthesis Purkinje Cells - enzymology
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Zusammenfassung:	Induction of NO-synthase and acetaldehyde dehydrogenase in Purkinje cells, basket-like neurons, and microvascular endothelium of human cerebellar cortex was detected in patients with chronic alcohol intoxication. It was hypothesized that the neuromodulating effect of NO is associated with mechanisms protecting neurons from toxic effects of ethanol and acetaldehyde.
ISSN:	0007-4888 1573-8221
DOI:	10.1023/B:BEBM.0000028142.86579.50