Anticoagulant activity of fucoidan from brown algae Fucus evanescens of the Okhotsk Sea

Anticoagulant activity of fucoidan from brown algae Fucus evanescens of the Okhotsk Sea

In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III.

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Veröffentlicht in:Bulletin of experimental biology and medicine 2003-11, Vol.136 (5), p.471-473
Hauptverfasser: Kuznetsova, T A, Besednova, N N, Mamaev, A N, Momot, A P, Shevchenko, N M, Zvyagintseva, T N
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Anticoagulants - chemistry
Anticoagulants - pharmacology
Blood Coagulation Tests
Dose-Response Relationship, Drug
Fucus - chemistry
Heparin - pharmacology
Humans
Mice
Mice, Inbred BALB C
Oceans and Seas
Polysaccharides - chemistry
Polysaccharides - pharmacology
Russia
Time Factors
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Zusammenfassung:In vitro and in vivo experiments showed that anticoagulant activity of sulfated polysaccharide from Fucus evanescens (brown algae of the Okhotsk Sea) was similar to that of heparin. Anticoagulant properties of fucoidan are determined by thrombin inhibition mediated via plasma antithrombin III.
ISSN:0007-4888
1573-8221
DOI:10.1023/b:bebm.0000017096.72246.1f