US DOE Tri-Lab Research Effort to Provide Accelerator-Produced ^sup 225^Ac for Radiotherapy: 2018 Update

US DOE Tri-Lab Research Effort to Provide Accelerator-Produced ^sup 225^Ac for Radiotherapy: 2018 Update

Introduction: Research Effort to Provide Accelerator-Produced 225Ac for Radiotherapy will be presented with focus on accelerator-production and final product isolation methodologies. In addition, impacts on the radionuclidic quality of the accelerator-produced 225Ac product will be presented. Specif...

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Veröffentlicht in:The Journal of nuclear medicine (1978) 2018-05, Vol.59, p.1044
Hauptverfasser: John, Kevin, Birnbaum, Eva, Boll, Rose, Brown, Ariel, Brugh, Mark, Cooley, Jason, Copping, Roy, Cutler, Cathy, Davern, Sandra, Denton, David, Fassbender, Michael, Felker, Kevin, Fitzsimmons, Jonathan, Griswold, Justin, Mastren, Tara, Medvedev, Dmitri, Mirzadeh, Saed, Murphy, Karen, Nortier, F Meiring, Olivas, Eric, Owens, Allison, Runde, Wolfgang, Stracener, Daniel, Wyant, Lance, Vermeulen, Etienne
Format: Artikel
Sprache:eng
Schlagworte:
Dosimeters
Dosimetry
Particle accelerators
Product quality
Radiation therapy
Toxicity
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Zusammenfassung:Introduction: Research Effort to Provide Accelerator-Produced 225Ac for Radiotherapy will be presented with focus on accelerator-production and final product isolation methodologies. In addition, impacts on the radionuclidic quality of the accelerator-produced 225Ac product will be presented. Specifics regarding ongoing evaluations of the accelerator-produced 225Ac by independent end-users related to pre-clinical dosimetry and toxicity studies and broad logistical challenges associated with the accelerator-based production approach (including plans for scale-up and our general strategy for GMP compliance) will also be discussed. LA-UR-18-20032
ISSN:0161-5505
1535-5667