Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids

Synthesis and Anticholinesterase Activity of [(4Z)-2-Aryl-4-(arylmethylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl]alkanoic Acids

ω-[(4 Z )-2-Aryl-4-arylmethylidene-5-oxo-4,5-dihydro-1 H -imidazol-1-yl]alkanoic acids were synthesized by reaction of N-substituted α,β-dehydropeptides with chloro(trimethyl)silane or 1,1,1,3,3,3-hexamethyldisilazane. Both initial peptides and (4 H )-imidazol-5-one derivatives based thereon were te...

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Veröffentlicht in:Russian journal of organic chemistry 2018-09, Vol.54 (9), p.1369-1377
Hauptverfasser: Topuzyan, V. O., Kazoyan, V. M., Tamazyan, R. A., Aivazyan, A. G., Galstyan, L. Kh
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Chemical synthesis
Chemistry
Chemistry and Materials Science
Organic Chemistry
Peptides
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Zusammenfassung:ω-[(4 Z )-2-Aryl-4-arylmethylidene-5-oxo-4,5-dihydro-1 H -imidazol-1-yl]alkanoic acids were synthesized by reaction of N-substituted α,β-dehydropeptides with chloro(trimethyl)silane or 1,1,1,3,3,3-hexamethyldisilazane. Both initial peptides and (4 H )-imidazol-5-one derivatives based thereon were tested for anticholinesterase activity.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428018090178