Carbotrifluoromethylation of Allylic Alcohols via 1,2‐Aryl Migration Promoted by Visible‐Light‐Induced Photoredox Catalysis

Carbotrifluoromethylation of Allylic Alcohols via 1,2‐Aryl Migration Promoted by Visible‐Light‐Induced Photoredox Catalysis

Visible‐light‐enabled photocatalytic carbotrifluoro‐methylations of allylic alcohols and sodium triflinate were explored through 1,2‐migration of an aryl group, affording an efficient method for synthesis of β‐trifluoromethyl‐α‐substituted carbonyl compounds under mild reaction conditions. This cata...

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Veröffentlicht in:Advanced synthesis & catalysis 2018-11, Vol.360 (21), p.4084-4088
Hauptverfasser: Cai, Shunyou, Tian, Yu, Zhang, Jinwang, Liu, Zhiji, Lu, Maojian, Weng, Wen, Huang, Mingqiang
Format: Artikel
Sprache:eng
Schlagworte:
1,2-aryl migration
Alcohol
Alcohols
Aromatic compounds
Carbonyl compounds
Carbonyls
carbotrifluoromethylation
Chemical synthesis
Functional groups
Langlois reagent
Migration
Photocatalysis
Photoredox catalysis
trifluoromethyl radical
visible light
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Zusammenfassung:Visible‐light‐enabled photocatalytic carbotrifluoro‐methylations of allylic alcohols and sodium triflinate were explored through 1,2‐migration of an aryl group, affording an efficient method for synthesis of β‐trifluoromethyl‐α‐substituted carbonyl compounds under mild reaction conditions. This catalyst system is well tolerant of various synthetically useful functional groups.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201800726