Selective Serotonin Reuptake Inhibitors: Implications for Advanced Nursing Practice

The efficacy of SSRIs in treating depression as compared to other classes of antidepressants is well documented. There is a growing body of knowledge documenting differences and similarities among these drugs, including half-life elimination, side effects, drug interactions, dosing and cost. These data must be reviewed before prescribing. Providers must take caution when giving SSRIs to patients who have been on other antipsychotics, especially MAO inhibitors, elderly patients, patients who are pregnant, and patients on type 1C antiarrhythmia agents.