Ultralow sensing limit in optofluidic micro-bottle resonator biosensor by self-referenced differential-mode detection scheme

Ultralow sensing limit in optofluidic micro-bottle resonator biosensor by self-referenced differential-mode detection scheme

Biosensors based on optofluidic micro-bottle resonators are demonstrated. A self-referenced sensing scheme, differential mode sensing, is proposed and used to substantially suppress environmental noises and reach an ultralow noise equal detection limit of 10 fg/ml (∼0.15 fM) for bovine serum albumin...

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Veröffentlicht in:Applied physics letters 2014-01, Vol.104 (3)
Hauptverfasser: Zhang, Xingwang, Liu, Liying, Xu, Lei
Format: Artikel
Sprache:eng
Schlagworte:
Applied physics
Biosensors
Detection
Resonators
Serum albumin
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Zusammenfassung:Biosensors based on optofluidic micro-bottle resonators are demonstrated. A self-referenced sensing scheme, differential mode sensing, is proposed and used to substantially suppress environmental noises and reach an ultralow noise equal detection limit of 10 fg/ml (∼0.15 fM) for bovine serum albumin molecules. This sensing scheme has high compatibility with any other microcavity sensors to get lower biosensing limit.
ISSN:0003-6951
1077-3118
DOI:10.1063/1.4861596