Impaired nitric oxide synthas pathway in diabetes mellitus: Role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase

Impaired nitric oxide synthas pathway in diabetes mellitus: Role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase

BACKGROUND: An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes elevated in DM. METHODS AND RESULTS: Male Sprague-Dawley rats were fed normal chow or...

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Veröffentlicht in:Circulation (New York, N.Y.) N.Y.), 2002-08, Vol.106 (8), p.987
Hauptverfasser: Lin, Ken Y, Ito, Akira, Asagami, Tomoko, Tsao, Philip S
Format: Artikel
Sprache:eng
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Zusammenfassung:BACKGROUND: An endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA), is elevated in patients with type 2 diabetes mellitus (DM). This study explored the mechanisms by which ADMA becomes elevated in DM. METHODS AND RESULTS: Male Sprague-Dawley rats were fed normal chow or high-fat diet (n=5 in each) with moderate streptozotocin injection to induce type 2 DM. Plasma ADMA was elevated in diabetic rats (1.33+/-0.31 versus 0.48+/-0.08 micromol/L; P
ISSN:0009-7322
1524-4539