Effect of carvedilol on the morbidity of patients with severe chronic heart failure: Results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study

Beta-blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure. We randomly assigned 2289 patients with symptoms of heart failure at rest or on minimal exertion and with an ejection...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2002-10, Vol.106 (17), p.2194-2199
Hauptverfasser:	PACKER, Milton, FOWLER, Michael B, HOLCSLAW, Terry L, AMANN-ZALAN, Ildiko, DEMETS, David L, ROECKER, Ellen B, COATS, Andrew J. S, KATUS, Hugo A, KRUM, Henry, MOHACSI, Paul, ROULEAU, Jean L, TENDERA, Michal, STAIGER, Christoph
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - adverse effects Adrenergic beta-Antagonists - therapeutic use Antiarythmic agents Biological and medical sciences Carbazoles - adverse effects Carbazoles - therapeutic use Cardiovascular system Carvedilol Chronic Disease Disease-Free Survival Double-Blind Method Health Resources - statistics & numerical data Heart Failure - diagnosis Heart Failure - drug therapy Heart Failure - mortality Hospitalization Humans Medical sciences Pharmacology. Drug treatments Propanolamines - adverse effects Propanolamines - therapeutic use Risk Survival Rate
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Beta-blocking agents improve functional status and reduce morbidity in mild-to-moderate heart failure, but it is not known whether they produce such benefits in severe heart failure. We randomly assigned 2289 patients with symptoms of heart failure at rest or on minimal exertion and with an ejection fraction
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.CIR.0000035653.72855.BF