Losartan in heart failure : hemodynamic effects and tolerability

Background The aim of the present study was to assess the short- and long-term effects of multiple doses of the angiotensin II receptor antagonist losartan in heart failure. Methods and Results A multicenter, placebo-controlled, oral, multidose (2.5, 10, 25, and 50 mg losartan once daily) double-bli...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1995-02, Vol.91 (3), p.691-697
Hauptverfasser:	CROZIER, I, IKRAM, H, RUCINSKA, E, NAJAM AWAN, CLELAND, J, STEPHEN, N, DICKSTEIN, K, FREY, M, YOUNG, J, KLINGER, G, MAKRIS, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiovascular system Medical sciences Pharmacology. Drug treatments Vasodilator agents. Cerebral vasodilators
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Beschreibung
Zusammenfassung:	Background The aim of the present study was to assess the short- and long-term effects of multiple doses of the angiotensin II receptor antagonist losartan in heart failure. Methods and Results A multicenter, placebo-controlled, oral, multidose (2.5, 10, 25, and 50 mg losartan once daily) double-blind comparison in patients with symptomatic heart failure and impaired left ventricular function (ejection fraction
ISSN:	0009-7322 1524-4539
DOI:	10.1161/01.cir.91.3.691