Genetics of Childhood Disorders: XII. Genomic Imprinting: Breaking the Rules

Genomic imprinting refers to a process that distinguishes paternally derived chromosomes from maternally derived chromosomes. Everman and Cassidy review how imprinting was initially identified, present some hypotheses about the mechanisms of imprinting, and speculate on the evolutionary forces maint...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Academy of Child and Adolescent Psychiatry 2000-03, Vol.39 (3), p.386-389
Hauptverfasser:	EVERMAN, DAVID B., CASSIDY, SUZANNE B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angelman Syndrome - genetics Biological and medical sciences Child Child development Child, Preschool Children & youth Chromosome Deletion Chromosome Mapping Chromosomes, Human, Pair 15 Complex syndromes Female Genetics Genomic Imprinting - genetics Humans Ligases - genetics Male Medical disorders Medical genetics Medical sciences Neurology Prader-Willi Syndrome - diagnosis Prader-Willi Syndrome - genetics Ubiquitin-Protein Ligases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Genomic imprinting refers to a process that distinguishes paternally derived chromosomes from maternally derived chromosomes. Everman and Cassidy review how imprinting was initially identified, present some hypotheses about the mechanisms of imprinting, and speculate on the evolutionary forces maintaining this phenomenon. They also discuss the molecular bases for two disorders in which imprinting is involved--Prader-Willi and Angelman syndromes.
ISSN:	0890-8567 1527-5418
DOI:	10.1097/00004583-200003000-00022