Optical-resolution photoacoustic imaging through thick tissue with a thin capillary as a dual optical-in acoustic-out waveguide
We demonstrate the ability to guide high-frequency photoacoustic waves through thick tissue with a water-filled silica-capillary (150 μm inner diameter and 30 mm long). An optical-resolution photoacoustic image of a 30 μm diameter absorbing nylon thread was obtained by guiding the acoustic waves in...
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Veröffentlicht in: | Applied physics letters 2015-03, Vol.106 (9) |
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Sprache: | eng |
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Zusammenfassung: | We demonstrate the ability to guide high-frequency photoacoustic waves through thick tissue with a water-filled silica-capillary (150 μm inner diameter and 30 mm long). An optical-resolution photoacoustic image of a 30 μm diameter absorbing nylon thread was obtained by guiding the acoustic waves in the capillary through a 3 cm thick fat layer. The transmission loss through the capillary was about −20 dB, much lower than the −120 dB acoustic attenuation through the fat layer. The overwhelming acoustic attenuation of high-frequency acoustic waves by biological tissue can therefore be avoided by the use of a small footprint capillary acoustic waveguide for remote detection. We finally demonstrate that the capillary can be used as a dual optical-in acoustic-out waveguide, paving the way for the development of minimally invasive optical-resolution photoacoustic endoscopes free of any acoustic or optical elements at their imaging tip. |
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ISSN: | 0003-6951 1077-3118 |
DOI: | 10.1063/1.4913969 |