Distribution of a Persistent Sodium Current Across the Ventricular Wall in Guinea Pigs

A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes by whole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium, midmyocardium, and subepicardium. Midmyocardial cells show a statistica...

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Veröffentlicht in:	Circulation research 2000-11, Vol.87 (10), p.910-914
Hauptverfasser:	Sakmann, Bernhard F.A.S, Spindler, Anthony J, Bryant, Simon M, Linz, Klaus W, Noble, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Biological and medical sciences Cadmium - pharmacology Calcium Channels - drug effects Computer Simulation Fundamental and applied biological sciences. Psychology Guinea Pigs Heart Heart Ventricles - cytology Heart Ventricles - drug effects Heart Ventricles - metabolism In Vitro Techniques Lithium Chloride - pharmacology Models, Cardiovascular Myocardium - cytology Myocardium - metabolism Organ Specificity - physiology Patch-Clamp Techniques Sodium - metabolism Sodium Channels - drug effects Sodium Channels - metabolism Sodium-Calcium Exchanger - drug effects Tetrodotoxin - pharmacology Vertebrates: cardiovascular system
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Zusammenfassung:	A tetrodotoxin-sensitive persistent sodium current, IpNa, was found in guinea pig ventricular myocytes by whole-cell patch clamping. This current was characterized in cells derived from the basal left ventricular subendocardium, midmyocardium, and subepicardium. Midmyocardial cells show a statistically significant (P
ISSN:	0009-7330 1524-4571
DOI:	10.1161/01.res.87.10.910