Cholesterol-dependent regulation of nitric oxide production: potential role in atherosclerosis

Atherosclerosis is preceded by cholesterol-induced diminution in vascular nitric oxide (NO) production and proatherogenic changes in endothelial cell function. Careful dissection of the steps involved in regulating endothelial nitric oxide synthase (eNOS) activity has revealed that cholesterol-induc...

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Veröffentlicht in:	Nutrition reviews 1999-09, Vol.57 (9), p.279-282
Hauptverfasser:	Jameson, R, Baum, C.L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis - etiology atherosclerosis Atherosclerosis (general aspects, experimental research) Biological and medical sciences biosynthesis Blood and lymphatic vessels Cardiology. Vascular system Caveolin 1 Caveolins Cholesterol Cholesterol - adverse effects Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - metabolism Humans Lipids Medical disorders Medical sciences Membrane Proteins - pharmacology nitric oxide Nitric Oxide - biosynthesis Nitric Oxide - physiology Nitric Oxide Synthase - metabolism Nutrition regulation
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Beschreibung
Zusammenfassung:	Atherosclerosis is preceded by cholesterol-induced diminution in vascular nitric oxide (NO) production and proatherogenic changes in endothelial cell function. Careful dissection of the steps involved in regulating endothelial nitric oxide synthase (eNOS) activity has revealed that cholesterol-induced caveolin expression reduces NO production by stimulating the production of inhibitory caveolin eNOS complexes.
ISSN:	0029-6643 1753-4887
DOI:	10.1111/j.1753-4887.1999.tb01812.x