Synthesis of Some Novel Flavonol Derivatives and its Microbial Activity

A series of flavonol derivatives were synthesized according to Algar-Flym-Oyamada reactions and chalcone were was synthesis according to the Claisen-Schmidt reactions. Chalcones were prepared by condensing equimolar of o-hydroxy acetophenones with 6-methoxynapthadehyde in alcoholic alkaline medium at room temperature. The resultant chalcones were immediately reacted with H2O2 in the presence of a mixture of aqeous alcoholic alkali to obtained corresponding flavonol. All the syntesized flavonol were characterized by means of their, IR, 1HNMR, Mass spectral data, elemental analysis and their physical properties. All flavonol were tested for their anfifungal and antibacterial activity. All the sysntesized flavonol exhibited moderate to good antimicrobial activity.