Studies on Synthesis and Antibacterial Activity of Some New 3-(2-Hydroxyphenyl)-4-Benzoyl-5-Phenylisoxazolines

Studies on Synthesis and Antibacterial Activity of Some New 3-(2-Hydroxyphenyl)-4-Benzoyl-5-Phenylisoxazolines

3-Aroyl flavanones (1a-j) were allowed to react with NH2 OH- HCl in dioxane containing piperidine to give the corresponding 3-(2-hydroxyphenyl)-4-aroyl-5-arylisoxazolines (2a-j). There structural assignment are based on the elemental analysis, spectra data (IR, UV & NMR) and chemical properties....

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Veröffentlicht in:Oriental journal of chemistry 2009-01, Vol.25 (2), p.409
Hauptverfasser: Bhise, Madhuri P, Raut, V M, Pawar, R P, Gulwade, D P, Junghare, N A
Format: Artikel
Sprache:eng
Schlagworte:
Chemical compounds
Chemical properties
Infrared radiation
NMR
Nuclear magnetic resonance
Organic chemistry
Piperidine
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Zusammenfassung:3-Aroyl flavanones (1a-j) were allowed to react with NH2 OH- HCl in dioxane containing piperidine to give the corresponding 3-(2-hydroxyphenyl)-4-aroyl-5-arylisoxazolines (2a-j). There structural assignment are based on the elemental analysis, spectra data (IR, UV & NMR) and chemical properties. All these compounds were tested in vitro for their antibacterial activity by disk-diffusion method against Gram positive and Gram negative bacterials. In some of the compounds the results are found to be encouraging.
ISSN:0970-020X
2231-5039