Tandem Reactions Using Nitrile Imines: Synthesis of Some Novel Heterocyclic Compounds with Expected Biological Activity

Tandem Reactions Using Nitrile Imines: Synthesis of Some Novel Heterocyclic Compounds with Expected Biological Activity

New functionalized 7,9-dimethylpyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidine-5,6,8(1H,7H,9H)-trione derivatives were synthesized via reaction of the hydrazonoyl halides with 7,8-dihydro-1,3-dimethyl-7-thioxopyrimido[4,5-d]pyrimidine-2,4,5(1H,3H,6H)trione. The biological activity of the products ha...

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Veröffentlicht in:Oriental journal of chemistry 2016, Vol.32 (1), p.148-158
Hauptverfasser: Gobouri, Adil, Mohamed, Mosselhi, Amin, Mahmoud
Format: Artikel
Sprache:eng
Schlagworte:
Biological activity
Cascade chemical reactions
Chemical synthesis
Halides
Heterocyclic compounds
Imines
Phosphorus
Regioselectivity
Sulfur
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Zusammenfassung:New functionalized 7,9-dimethylpyrimido[4,5-d][1,2,4]triazolo[4,3-a]pyrimidine-5,6,8(1H,7H,9H)-trione derivatives were synthesized via reaction of the hydrazonoyl halides with 7,8-dihydro-1,3-dimethyl-7-thioxopyrimido[4,5-d]pyrimidine-2,4,5(1H,3H,6H)trione. The biological activity of the products has been evaluated. The mechanism and the regioselectivity of the studied reactions have been discussed.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/320115