Towards the First Total Synthesis and Anticancer Screening of Polycarponin C: A Cyclic Octapeptide

The present study describes designing, synthesis and anticancer screening of a proline rich cyclic octapeptide polycarponin C, by solution phase synthesis. The synthesis was carried out by coupling a tetrapeptide Boc-Pro-Thr-Leu-Pro-OH with another tetrapeptide Boc-Pro-Val-Leu-Phe-OH, followed by cyclization of the linear fragment.The structure of the synthesized compound was then confirmed by spectral analysis. From the results of biological activity, it was concluded that, the compound had shown moderate activity against SR human tumor cell lines of Leukemia when compared with Vincristine as a standard.