Poly (rhodamine B) sensor for norepinephrine and paracetamol: a voltammetric study

A voltammetric study of norepinephrine (NE) in the presence of paracetamol (PA) was carried out using a poly (rhodamine B)-modified carbon paste electrode (CPE). The poly (rhodamine B) electrode was fabricated by potential cyclic voltammetry using a rhodamine B monomer. The modified electrode exhibited a good affirmative response towards the electrooxidation of NE and PA in physiological pH 7.4 phosphate buffer solution (PBS). The influence of sweep rates and pH (6.2 to 7.8) was studied. The simultaneous electroanalysis of NE and PA and the interference study were investigated by CV and DPV. The modified electrode showed good selectivity and sensitivity with a detection limit of NE of 1.8 μM and PA of 2.2 μM. The real sample analysis of the proposed method is studied by determining the NE in the injection sample and PA in a commercial tablet sample with good recovery results obtained.