The Biginelli Reaction

The utilization of the Biginelli reaction, a one-pot condensation of an aldehyde, a β-keto ester, and urea, is described. This reaction involves a number of individual steps, each of which is accessible to first-year organic students. The product, a 3,4-dihydropyrimidinone, is a member of a medicina...

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Veröffentlicht in:	Journal of chemical education 2001-08, Vol.78 (8), p.1104
Hauptverfasser:	Holden, Michael S, Crouch, R. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical reactions Chemistry Science education Simulation
Online-Zugang:	Volltext
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