The Biginelli Reaction
The utilization of the Biginelli reaction, a one-pot condensation of an aldehyde, a β-keto ester, and urea, is described. This reaction involves a number of individual steps, each of which is accessible to first-year organic students. The product, a 3,4-dihydropyrimidinone, is a member of a medicina...
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| Veröffentlicht in: | Journal of chemical education 2001-08, Vol.78 (8), p.1104 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The utilization of the Biginelli reaction, a one-pot condensation of an aldehyde, a β-keto ester, and urea, is described. This reaction involves a number of individual steps, each of which is accessible to first-year organic students. The product, a 3,4-dihydropyrimidinone, is a member of a medicinally useful class of compounds. The reaction is simple to perform and the product precipitates from solution in an extremely pure form. |
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| ISSN: | 0021-9584 1938-1328 |
| DOI: | 10.1021/ed078p1104 |