Simultaneous determination of the ionization constant and the solubility of sparingly soluble drug substances

An experiment is presented in which students determine the ionization constant and solubility of the basic form of a sparingly soluble drug substance, using the inverse titration method with dissolution of a precipitate. Students carry out three independent statistical analyses of the data and discu...

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Veröffentlicht in:Journal of chemical education 2001-06, Vol.78 (6), p.786
Hauptverfasser: Aroti, Andria, Leontidis, Epameinondas
Format: Artikel
Sprache:eng
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Zusammenfassung:An experiment is presented in which students determine the ionization constant and solubility of the basic form of a sparingly soluble drug substance, using the inverse titration method with dissolution of a precipitate. Students carry out three independent statistical analyses of the data and discuss their merits and complementary nature.
ISSN:0021-9584
1938-1328