The Use of Ethyl Cellulose Polymer to Control Drug Release of Hydrocortisone Acetate

There are considerable numbers of medicines that cannot be dissolved in water or have a little aqueous solubility, and this causes problems in their absorption and reduction of bioavailability of them subsequently. A variety of methods have been developed to increase the solubility of drugs to treat these problems. In this study, ethyl cellulose polymers have been used to deliver hydrocortisone acetate drugs. In this way, solvent evaporation technique was considered to increase the solubility of the drug hydrocortisone acetate. Scanning electron microscopy (SEM) was usedto determine the shape and size of the microcapsules.The infrared spectroscopy (FT-IR) was also applied to investigate that if any change was happened in the structure of drug during the micro capsulation process.