Synthesis and Characterization of some new β-Lactam Derivatives from Azo Sulphadiazine and its Biological Evaluation as Anticancer

In this work new Azo compound was synthesized through a diazo-coupling reaction (S1) (4-amino-N-(pyrimidine-2-yl)-3-( pyrimidine-2-yldiazenyl)benzene sulfonamide). The diazotization process of 2-aminopyrimidin with Sulphadiazine as coupling component was described, then schiff bases [B1-B5] prepared...

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Veröffentlicht in:Oriental journal of chemistry 2018-01, Vol.34 (1), p.371-380
Hauptverfasser: Khdur, Radhiyah A, Zimam, Ezzat H
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Sprache:eng
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Zusammenfassung:In this work new Azo compound was synthesized through a diazo-coupling reaction (S1) (4-amino-N-(pyrimidine-2-yl)-3-( pyrimidine-2-yldiazenyl)benzene sulfonamide). The diazotization process of 2-aminopyrimidin with Sulphadiazine as coupling component was described, then schiff bases [B1-B5] prepared from condensation of the free amino group in the azo compound with many aromatic aldehydes by using glacial Acetic acid as solvent. cyclization of Shiff bases with Chloro acetyl chloride in the presence of tri ethyl amine give the corresponding β-lactam derivatives [L1-L5]. All these compounds identified by( FT-IR,1H-NMR, 13C-NMR) and follow reaction by (TLC) and Measurement melting points of some them.
ISSN:0970-020X
2231-5039
DOI:10.13005/ojc/340140