Formulation of Liposome using Sappan wood (Caesalpinia Sappan L.) Ethyl acetate Fraction as an activate compound
The purpose of this study is to determine the characteristics of liposome containing Sappan wood ethyl acetate fraction (SWEAF) as an active compound. Liposome was prepared by using two methods: Thin Layer Hydration (TLH) and Reversed Phase Evaporation (REV) methods. Liposome composition was 1 part...
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| Veröffentlicht in: | Oriental journal of chemistry 2018-01, Vol.34 (3), p.1611-1618 |
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| container_title | Oriental journal of chemistry |
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| creator | Noviza, Deni Lucida, Henny Suharti, Netty Bhana Pinto, Putri |
| description | The purpose of this study is to determine the characteristics of liposome containing Sappan wood ethyl acetate fraction (SWEAF) as an active compound. Liposome was prepared by using two methods: Thin Layer Hydration (TLH) and Reversed Phase Evaporation (REV) methods. Liposome composition was 1 part of the SWEAF and 6 parts of the liposome component (phosphatidyl choline and cholesterol with an equally large molar ratio). Both methods produce red-colored liposome dispersion. When examined with transmission electrone microscope, both methods yielded a spherical and unilamellar liposome. The TLH method produces liposome with a particle size of 2,304.5 ± 528.9 nm. The REV method yields a liposome with a particle size of 2,643.5 ± 350.8 nm. The polydispersity index shows the distribution of liposome size. The TLH method produces liposome with a polydispersity index of 1,490 ± 0.284. The REV method produces liposome with a polydispersity index of 1.987 ± 0.901. |
| doi_str_mv | 10.13005/ojc/340355 |
| format | Article |
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Ethyl acetate Fraction as an activate compound</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Noviza, Deni ; Lucida, Henny ; Suharti, Netty ; Bhana Pinto, Putri</creator><creatorcontrib>Noviza, Deni ; Lucida, Henny ; Suharti, Netty ; Bhana Pinto, Putri</creatorcontrib><description>The purpose of this study is to determine the characteristics of liposome containing Sappan wood ethyl acetate fraction (SWEAF) as an active compound. Liposome was prepared by using two methods: Thin Layer Hydration (TLH) and Reversed Phase Evaporation (REV) methods. Liposome composition was 1 part of the SWEAF and 6 parts of the liposome component (phosphatidyl choline and cholesterol with an equally large molar ratio). Both methods produce red-colored liposome dispersion. When examined with transmission electrone microscope, both methods yielded a spherical and unilamellar liposome. The TLH method produces liposome with a particle size of 2,304.5 ± 528.9 nm. The REV method yields a liposome with a particle size of 2,643.5 ± 350.8 nm. The polydispersity index shows the distribution of liposome size. The TLH method produces liposome with a polydispersity index of 1,490 ± 0.284. The REV method produces liposome with a polydispersity index of 1.987 ± 0.901.</description><identifier>ISSN: 0970-020X</identifier><identifier>EISSN: 2231-5039</identifier><identifier>DOI: 10.13005/ojc/340355</identifier><language>eng</language><publisher>Bhopal: Oriental Scientific Publishing Company</publisher><subject>Antioxidants ; Cholesterol ; Choline ; Drug delivery systems ; Drugs ; Ethanol ; Ethyl acetate ; Lipids ; Methods ; Microscopy ; Particle size ; Phosphatidylcholine ; Polydispersity ; Production methods ; Solvents</subject><ispartof>Oriental journal of chemistry, 2018-01, Vol.34 (3), p.1611-1618</ispartof><rights>2018. 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The TLH method produces liposome with a polydispersity index of 1,490 ± 0.284. The REV method produces liposome with a polydispersity index of 1.987 ± 0.901.</description><subject>Antioxidants</subject><subject>Cholesterol</subject><subject>Choline</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Ethanol</subject><subject>Ethyl acetate</subject><subject>Lipids</subject><subject>Methods</subject><subject>Microscopy</subject><subject>Particle size</subject><subject>Phosphatidylcholine</subject><subject>Polydispersity</subject><subject>Production methods</subject><subject>Solvents</subject><issn>0970-020X</issn><issn>2231-5039</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNo1kE1Lw0AQhhdRsNSe_AMLXhRJO7ubzTZHKa0KAQ8qeAv7FU1JsutuYum_N211LsPMPLwDD0LXBOaEAfCF2-oFS4FxfoYmlDKScGD5OZpALiABCh-XaBbjFsbKU5YRPkF-40I7NLKvXYddhYvau-hai4dYd5_4VXovO7xzzuDblbRRNr7uavl_KOZ3eN1_7Rsste1lb_EmSH0MkxGPwGH4Oey1a70bOnOFLirZRDv761P0vlm_rZ6S4uXxefVQJJryrE8YVJUyRGc0JWlqqRIqV0JUOqsyy5QgS8u4MUvBOAGtZS4saJsbIahSxig2RTenXB_c92BjX27dELrxZUkJESRfguAjdX-idHAxBluVPtStDPuSQHm0Wo5Wy5NV9gvvhWsy</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Noviza, Deni</creator><creator>Lucida, Henny</creator><creator>Suharti, Netty</creator><creator>Bhana Pinto, Putri</creator><general>Oriental Scientific Publishing Company</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20180101</creationdate><title>Formulation of Liposome using Sappan wood (Caesalpinia Sappan L.) 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Ethyl acetate Fraction as an activate compound</atitle><jtitle>Oriental journal of chemistry</jtitle><date>2018-01-01</date><risdate>2018</risdate><volume>34</volume><issue>3</issue><spage>1611</spage><epage>1618</epage><pages>1611-1618</pages><issn>0970-020X</issn><eissn>2231-5039</eissn><abstract>The purpose of this study is to determine the characteristics of liposome containing Sappan wood ethyl acetate fraction (SWEAF) as an active compound. Liposome was prepared by using two methods: Thin Layer Hydration (TLH) and Reversed Phase Evaporation (REV) methods. Liposome composition was 1 part of the SWEAF and 6 parts of the liposome component (phosphatidyl choline and cholesterol with an equally large molar ratio). Both methods produce red-colored liposome dispersion. When examined with transmission electrone microscope, both methods yielded a spherical and unilamellar liposome. The TLH method produces liposome with a particle size of 2,304.5 ± 528.9 nm. 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| subjects | Antioxidants Cholesterol Choline Drug delivery systems Drugs Ethanol Ethyl acetate Lipids Methods Microscopy Particle size Phosphatidylcholine Polydispersity Production methods Solvents |
| title | Formulation of Liposome using Sappan wood (Caesalpinia Sappan L.) Ethyl acetate Fraction as an activate compound |
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